| Irvine to Oswego (Illinois) | 3,694.15 mi (5,945.16 km) |
| Irvine to Oswego (New York) | 3,174.37 mi (5,108.65 km) |
| Irvine to Otsego (Minnesota) | 3,702.96 mi (5,959.33 km) |
| Irvine to Ottawa (Illinois) | 3,728.02 mi (5,999.68 km) |
| Irvine to Ottawa (Kansas) | 4,098.57 mi (6,596.01 km) |
| Irvine to Ottumwa (Iowa) | 3,873.31 mi (6,233.48 km) |
| Irvine to Overland (Missouri) | 3,917.85 mi (6,305.17 km) |
| Irvine to Overland Park (Kansas) | 4,063.17 mi (6,539.04 km) |
| Irvine to Overlea (Maryland) | 3,368.01 mi (5,420.28 km) |
| Irvine to Oviedo (Florida) | 4,093.93 mi (6,588.55 km) |
| Irvine to Owasso (Oklahoma) | 4,240.21 mi (6,823.95 km) |
| Irvine to Owatonna (Minnesota) | 3,747.69 mi (6,031.33 km) |
| Irvine to Owensboro (Kentucky) | 3,846.37 mi (6,190.14 km) |
| Irvine to Owings Mills (Maryland) | 3,376.15 mi (5,433.39 km) |
| Irvine to Owosso (Michigan) | 3,479.47 mi (5,599.66 km) |
