| Irvine to Orangevale (California) | 4,933.89 mi (7,940.33 km) |
| Irvine to Orchards (Washington) | 4,562.62 mi (7,342.83 km) |
| Irvine to Orcutt (California) | 5,134.13 mi (8,262.59 km) |
| Irvine to Oregon (Ohio) | 3,516.86 mi (5,659.84 km) |
| Irvine to Oregon (Wisconsin) | 3,670.60 mi (5,907.26 km) |
| Irvine to Oregon City (Oregon) | 4,584.36 mi (7,377.81 km) |
| Irvine to Orem (Utah) | 4,556.45 mi (7,332.90 km) |
| Irvine to Orinda (California) | 5,008.71 mi (8,060.75 km) |
| Irvine to Orland Park (Illinois) | 3,680.75 mi (5,923.59 km) |
| Irvine to Orlando (Florida) | 4,109.35 mi (6,613.35 km) |
| Irvine to Ormond Beach (Florida) | 4,056.63 mi (6,528.52 km) |
| Irvine to Oro Valley (Arizona) | 4,976.57 mi (8,009.02 km) |
| Irvine to Oroville (California) | 4,896.22 mi (7,879.71 km) |
| Irvine to Oshkosh (Wisconsin) | 3,587.69 mi (5,773.83 km) |
| Irvine to Oskaloosa (Iowa) | 3,867.35 mi (6,223.90 km) |
