| Irvine to Olympia Heights (Florida) | 4,218.07 mi (6,788.34 km) |
| Irvine to Omaha (Nebraska) | 3,988.35 mi (6,418.64 km) |
| Irvine to On Top of the World Designated Place (Florida) | 4,112.68 mi (6,618.72 km) |
| Irvine to Onalaska (Wisconsin) | 3,687.39 mi (5,934.29 km) |
| Irvine to Oneida (New York) | 3,160.14 mi (5,085.75 km) |
| Irvine to Oneonta (New York) | 3,166.40 mi (5,095.82 km) |
| Irvine to Ontario (California) | 5,096.74 mi (8,202.41 km) |
| Irvine to Ontario (Oregon) | 4,505.04 mi (7,250.16 km) |
| Irvine to Opa-locka (Florida) | 4,205.35 mi (6,767.85 km) |
| Irvine to Opelika (Alabama) | 4,043.84 mi (6,507.93 km) |
| Irvine to Opelousas (Louisiana) | 4,410.01 mi (7,097.23 km) |
| Irvine to Orange (California) | 5,117.11 mi (8,235.19 km) |
| Irvine to Orange (Texas) | 4,494.37 mi (7,232.99 km) |
| Irvine to Orange City (Florida) | 4,083.14 mi (6,571.18 km) |
| Irvine to Orangeburg (South Carolina) | 3,828.38 mi (6,161.18 km) |
