| Irvine to Odessa (Texas) | 4,710.43 mi (7,580.70 km) |
| Irvine to Ogden (Utah) | 4,513.02 mi (7,263.00 km) |
| Irvine to Oildale (California) | 5,059.50 mi (8,142.47 km) |
| Irvine to Ojus (Florida) | 4,198.62 mi (6,757.03 km) |
| Irvine to Okemos (Michigan) | 3,502.03 mi (5,635.97 km) |
| Irvine to Oklahoma City (Oklahoma) | 4,343.96 mi (6,990.93 km) |
| Irvine to Okmulgee (Oklahoma) | 4,282.26 mi (6,891.63 km) |
| Irvine to Olathe (Kansas) | 4,068.08 mi (6,546.94 km) |
| Irvine to Old Jamestown (Missouri) | 3,907.50 mi (6,288.52 km) |
| Irvine to Oldsmar (Florida) | 4,183.69 mi (6,733.00 km) |
| Irvine to Olean (New York) | 3,310.53 mi (5,327.78 km) |
| Irvine to Olive Branch (Mississippi) | 4,091.63 mi (6,584.84 km) |
| Irvine to Olivehurst (California) | 4,920.61 mi (7,918.96 km) |
| Irvine to Olney (Maryland) | 3,399.68 mi (5,471.25 km) |
| Irvine to Olympia (Washington) | 4,493.95 mi (7,232.31 km) |
