| Irvine to Oakley (California) | 4,988.24 mi (8,027.80 km) |
| Irvine to Oakton (Virginia) | 3,420.99 mi (5,505.55 km) |
| Irvine to Oakville (Missouri) | 3,928.78 mi (6,322.75 km) |
| Irvine to Oatfield (Oregon) | 4,580.31 mi (7,371.29 km) |
| Irvine to Ocala (Florida) | 4,103.61 mi (6,604.13 km) |
| Irvine to Ocean Acres (New Jersey) | 3,264.28 mi (5,253.36 km) |
| Irvine to Ocean City (New Jersey) | 3,299.42 mi (5,309.90 km) |
| Irvine to Ocean Pines (Maryland) | 3,363.19 mi (5,412.53 km) |
| Irvine to Ocean Pointe (Hawaii) | 6,895.67 mi (11,097.51 km) |
| Irvine to Ocean Springs (Mississippi) | 4,292.22 mi (6,907.66 km) |
| Irvine to Oceanside (California) | 5,134.78 mi (8,263.63 km) |
| Irvine to Oceanside (New York) | 3,197.30 mi (5,145.55 km) |
| Irvine to Ocoee (Florida) | 4,111.50 mi (6,616.83 km) |
| Irvine to Oconomowoc (Wisconsin) | 3,630.20 mi (5,842.24 km) |
| Irvine to Odenton (Maryland) | 3,389.18 mi (5,454.36 km) |
