| Irvine to Merrick (New York) | 3,193.24 mi (5,139.03 km) |
| Irvine to Merrifield (Virginia) | 3,419.50 mi (5,503.16 km) |
| Irvine to Merrillville (Indiana) | 3,667.76 mi (5,902.69 km) |
| Irvine to Merritt Island (Florida) | 4,092.22 mi (6,585.79 km) |
| Irvine to Mesa (Arizona) | 4,945.34 mi (7,958.76 km) |
| Irvine to Mesquite (Nevada) | 4,829.44 mi (7,772.23 km) |
| Irvine to Mesquite (Texas) | 4,455.93 mi (7,171.13 km) |
| Irvine to Metairie (Louisiana) | 4,366.80 mi (7,027.68 km) |
| Irvine to Methuen Town (Massachusetts) | 3,006.24 mi (4,838.07 km) |
| Irvine to Metuchen (New Jersey) | 3,229.33 mi (5,197.11 km) |
| Irvine to Mexico (Missouri) | 3,948.33 mi (6,354.23 km) |
| Irvine to Miami (Florida) | 4,209.83 mi (6,775.07 km) |
| Irvine to Miami (Oklahoma) | 4,174.15 mi (6,717.65 km) |
| Irvine to Miami Beach (Florida) | 4,205.30 mi (6,767.78 km) |
| Irvine to Miami Gardens (Florida) | 4,202.51 mi (6,763.29 km) |
