| Irvine to Medford (New York) | 3,163.48 mi (5,091.13 km) |
| Irvine to Medford (Oregon) | 4,766.27 mi (7,670.57 km) |
| Irvine to Medina (Ohio) | 3,484.01 mi (5,606.97 km) |
| Irvine to Medulla (Florida) | 4,162.24 mi (6,698.48 km) |
| Irvine to Mehlville (Missouri) | 3,925.84 mi (6,318.03 km) |
| Irvine to Melbourne (Florida) | 4,102.83 mi (6,602.87 km) |
| Irvine to Melissa (Texas) | 4,426.39 mi (7,123.59 km) |
| Irvine to Melrose (Massachusetts) | 3,013.97 mi (4,850.52 km) |
| Irvine to Melrose Park (Illinois) | 3,666.24 mi (5,900.24 km) |
| Irvine to Melville (New York) | 3,181.53 mi (5,120.18 km) |
| Irvine to Melvindale (Michigan) | 3,477.25 mi (5,596.09 km) |
| Irvine to Memphis (Florida) | 4,206.59 mi (6,769.85 km) |
| Irvine to Memphis (Tennessee) | 4,088.34 mi (6,579.55 km) |
| Irvine to Menasha (Wisconsin) | 3,573.73 mi (5,751.37 km) |
| Irvine to Mendota (California) | 5,022.33 mi (8,082.65 km) |
