| Irvine to McKeesport (Pennsylvania) | 3,446.68 mi (5,546.90 km) |
| Irvine to McKinleyville (California) | 4,881.31 mi (7,855.71 km) |
| Irvine to McKinney (Texas) | 4,435.08 mi (7,137.56 km) |
| Irvine to McLean (Virginia) | 3,414.23 mi (5,494.67 km) |
| Irvine to McMinnville (Oregon) | 4,607.76 mi (7,415.47 km) |
| Irvine to McMinnville (Tennessee) | 3,902.31 mi (6,280.16 km) |
| Irvine to McNair (Virginia) | 3,422.13 mi (5,507.38 km) |
| Irvine to McPherson (Kansas) | 4,195.00 mi (6,751.19 km) |
| Irvine to Mead Valley (California) | 5,098.72 mi (8,205.60 km) |
| Irvine to Meadow Woods (Florida) | 4,115.44 mi (6,623.17 km) |
| Irvine to Meadowbrook (Virginia) | 3,499.24 mi (5,631.48 km) |
| Irvine to Meadville (Pennsylvania) | 3,395.25 mi (5,464.13 km) |
| Irvine to Mebane (North Carolina) | 3,635.24 mi (5,850.36 km) |
| Irvine to Mechanicsville (Virginia) | 3,485.02 mi (5,608.60 km) |
| Irvine to Medford (Massachusetts) | 3,017.34 mi (4,855.95 km) |
