| Irvine to Los Alamos (New Mexico) | 4,625.18 mi (7,443.51 km) |
| Irvine to Los Altos (California) | 5,036.48 mi (8,105.44 km) |
| Irvine to Los Angeles (California) | 5,117.11 mi (8,235.19 km) |
| Irvine to Los Banos (California) | 5,017.94 mi (8,075.60 km) |
| Irvine to Los Gatos (California) | 5,040.55 mi (8,111.99 km) |
| Irvine to Los Lunas (New Mexico) | 4,701.70 mi (7,566.66 km) |
| Irvine to Los Osos (California) | 5,120.45 mi (8,240.57 km) |
| Irvine to Loudoun Valley Estates (Virginia) | 3,424.45 mi (5,511.11 km) |
| Irvine to Louisville (Colorado) | 4,364.18 mi (7,023.46 km) |
| Irvine to Louisville (Kentucky) | 3,771.20 mi (6,069.16 km) |
| Irvine to Lovejoy (Georgia) | 3,962.84 mi (6,377.58 km) |
| Irvine to Loveland (Colorado) | 4,337.41 mi (6,980.39 km) |
| Irvine to Loveland (Ohio) | 3,664.97 mi (5,898.20 km) |
| Irvine to Loves Park (Illinois) | 3,685.62 mi (5,931.43 km) |
| Irvine to Lovington (New Mexico) | 4,688.06 mi (7,544.70 km) |
