| Irvine to Largo (Florida) | 4,195.19 mi (6,751.50 km) |
| Irvine to Largo (Maryland) | 3,403.39 mi (5,477.22 km) |
| Irvine to Larkspur (California) | 5,015.34 mi (8,071.40 km) |
| Irvine to Las Cruces (New Mexico) | 4,840.49 mi (7,790.01 km) |
| Irvine to Las Vegas (Nevada) | 4,897.39 mi (7,881.58 km) |
| Irvine to Las Vegas (New Mexico) | 4,605.23 mi (7,411.40 km) |
| Irvine to Latham (New York) | 3,103.27 mi (4,994.23 km) |
| Irvine to Lathrop (California) | 4,988.00 mi (8,027.41 km) |
| Irvine to Lauderdale Lakes (Florida) | 4,188.81 mi (6,741.25 km) |
| Irvine to Lauderhill (Florida) | 4,190.10 mi (6,743.32 km) |
| Irvine to Laurel (Florida) | 4,223.48 mi (6,797.04 km) |
| Irvine to Laurel (Maryland) | 3,394.21 mi (5,462.45 km) |
| Irvine to Laurel (Mississippi) | 4,237.28 mi (6,819.24 km) |
| Irvine to Laurel (Virginia) | 3,490.21 mi (5,616.95 km) |
| Irvine to Laurinburg (North Carolina) | 3,710.11 mi (5,970.85 km) |
