| Irvine to Friendswood (Texas) | 4,580.93 mi (7,372.29 km) |
| Irvine to Frisco (Texas) | 4,443.13 mi (7,150.53 km) |
| Irvine to Front Royal (Virginia) | 3,452.75 mi (5,556.66 km) |
| Irvine to Fruit Cove (Florida) | 4,034.37 mi (6,492.70 km) |
| Irvine to Fruita (Colorado) | 4,525.70 mi (7,283.41 km) |
| Irvine to Fruitville (Florida) | 4,214.04 mi (6,781.83 km) |
| Irvine to Fuller Heights (Florida) | 4,164.51 mi (6,702.13 km) |
| Irvine to Fullerton (California) | 5,115.72 mi (8,232.96 km) |
| Irvine to Fullerton (Pennsylvania) | 3,267.85 mi (5,259.10 km) |
| Irvine to Fulshear (Texas) | 4,596.28 mi (7,396.99 km) |
| Irvine to Fulton (Missouri) | 3,966.97 mi (6,384.21 km) |
| Irvine to Fulton (New York) | 3,177.42 mi (5,113.56 km) |
| Irvine to Fuquay-Varina (North Carolina) | 3,640.94 mi (5,859.52 km) |
| Irvine to Gadsden (Alabama) | 3,997.80 mi (6,433.84 km) |
| Irvine to Gaffney (South Carolina) | 3,777.44 mi (6,079.20 km) |
