| Irvine to Euless (Texas) | 4,468.95 mi (7,192.08 km) |
| Irvine to Eureka (California) | 4,892.35 mi (7,873.47 km) |
| Irvine to Eureka (Missouri) | 3,938.06 mi (6,337.69 km) |
| Irvine to Eustis (Florida) | 4,102.36 mi (6,602.12 km) |
| Irvine to Evans (Colorado) | 4,329.50 mi (6,967.66 km) |
| Irvine to Evans (Georgia) | 3,873.40 mi (6,233.64 km) |
| Irvine to Evanston (Illinois) | 3,653.08 mi (5,879.06 km) |
| Irvine to Evanston (Wyoming) | 4,480.15 mi (7,210.10 km) |
| Irvine to Evansville (Indiana) | 3,850.08 mi (6,196.10 km) |
| Irvine to Everett (Massachusetts) | 3,016.05 mi (4,853.86 km) |
| Irvine to Everett (Washington) | 4,422.70 mi (7,117.64 km) |
| Irvine to Evergreen Park (Illinois) | 3,669.33 mi (5,905.21 km) |
| Irvine to Ewa Beach (Hawaii) | 6,895.07 mi (11,096.55 km) |
| Irvine to Ewa Gentry (Hawaii) | 6,894.30 mi (11,095.30 km) |
| Irvine to Excelsior Springs (Missouri) | 4,023.90 mi (6,475.84 km) |
