| Irvine to Enumclaw (Washington) | 4,461.20 mi (7,179.61 km) |
| Irvine to Ephrata (Pennsylvania) | 3,315.87 mi (5,336.37 km) |
| Irvine to Erie (Colorado) | 4,356.99 mi (7,011.90 km) |
| Irvine to Erie (Pennsylvania) | 3,370.18 mi (5,423.78 km) |
| Irvine to Erlanger (Kentucky) | 3,689.39 mi (5,937.49 km) |
| Irvine to Escanaba (Michigan) | 3,453.21 mi (5,557.41 km) |
| Irvine to Escondido (California) | 5,132.60 mi (8,260.13 km) |
| Irvine to Española (New Mexico) | 4,611.70 mi (7,421.81 km) |
| Irvine to Essex (Maryland) | 3,368.24 mi (5,420.66 km) |
| Irvine to Essex Junction (Vermont) | 3,000.16 mi (4,828.29 km) |
| Irvine to Estelle (Louisiana) | 4,372.14 mi (7,036.27 km) |
| Irvine to Estero (Florida) | 4,236.79 mi (6,818.46 km) |
| Irvine to Euclid (Ohio) | 3,449.08 mi (5,550.75 km) |
| Irvine to Eufaula (Alabama) | 4,074.58 mi (6,557.40 km) |
| Irvine to Eugene (Oregon) | 4,673.01 mi (7,520.48 km) |
