| Irvine to Emeryville (California) | 5,014.49 mi (8,070.04 km) |
| Irvine to Emmaus (Pennsylvania) | 3,272.95 mi (5,267.31 km) |
| Irvine to Emporia (Kansas) | 4,141.74 mi (6,665.49 km) |
| Irvine to Encinitas (California) | 5,143.49 mi (8,277.65 km) |
| Irvine to Endicott (New York) | 3,220.70 mi (5,183.21 km) |
| Irvine to Endwell (New York) | 3,218.16 mi (5,179.13 km) |
| Irvine to Englewood (Colorado) | 4,376.77 mi (7,043.73 km) |
| Irvine to Englewood (Florida) | 4,229.17 mi (6,806.20 km) |
| Irvine to Englewood (New Jersey) | 3,197.96 mi (5,146.61 km) |
| Irvine to Englewood (Ohio) | 3,636.66 mi (5,852.64 km) |
| Irvine to Enid (Oklahoma) | 4,306.53 mi (6,930.69 km) |
| Irvine to Ennis (Texas) | 4,481.15 mi (7,211.72 km) |
| Irvine to Ensley (Florida) | 4,228.54 mi (6,805.18 km) |
| Irvine to Enterprise (Alabama) | 4,131.77 mi (6,649.44 km) |
| Irvine to Enterprise (Nevada) | 4,909.06 mi (7,900.36 km) |
