| Irvine to Eau Claire (Wisconsin) | 3,651.75 mi (5,876.92 km) |
| Irvine to Echelon (New Jersey) | 3,286.61 mi (5,289.28 km) |
| Irvine to Eden (North Carolina) | 3,632.13 mi (5,845.34 km) |
| Irvine to Eden Prairie (Minnesota) | 3,718.04 mi (5,983.60 km) |
| Irvine to Edgewater (Florida) | 4,068.38 mi (6,547.42 km) |
| Irvine to Edgewater (New Jersey) | 3,201.18 mi (5,151.80 km) |
| Irvine to Edgewood (Maryland) | 3,356.92 mi (5,402.45 km) |
| Irvine to Edgewood (Washington) | 4,467.17 mi (7,189.21 km) |
| Irvine to Edina (Minnesota) | 3,712.53 mi (5,974.74 km) |
| Irvine to Edinburg (Texas) | 4,865.89 mi (7,830.90 km) |
| Irvine to Edmond (Oklahoma) | 4,329.73 mi (6,968.02 km) |
| Irvine to Edmonds (Washington) | 4,435.60 mi (7,138.40 km) |
| Irvine to Edwards (Colorado) | 4,431.53 mi (7,131.86 km) |
| Irvine to Edwardsville (Illinois) | 3,899.10 mi (6,275.00 km) |
| Irvine to Effingham (Illinois) | 3,830.07 mi (6,163.90 km) |
