| Irvine to East Rancho Dominguez (California) | 5,123.37 mi (8,245.27 km) |
| Irvine to East Renton Highlands (Washington) | 4,448.18 mi (7,158.66 km) |
| Irvine to East Ridge (Tennessee) | 3,916.94 mi (6,303.71 km) |
| Irvine to East Riverdale (Maryland) | 3,402.62 mi (5,475.99 km) |
| Irvine to East San Gabriel (California) | 5,106.92 mi (8,218.80 km) |
| Irvine to East St. Louis (Illinois) | 3,913.32 mi (6,297.88 km) |
| Irvine to East Wenatchee (Washington) | 4,403.95 mi (7,087.47 km) |
| Irvine to Eastern Goleta Valley (California) | 5,139.91 mi (8,271.89 km) |
| Irvine to Eastlake (Ohio) | 3,442.60 mi (5,540.34 km) |
| Irvine to Eastmont (Washington) | 4,426.28 mi (7,123.40 km) |
| Irvine to Easton (Maryland) | 3,379.46 mi (5,438.71 km) |
| Irvine to Easton (Pennsylvania) | 3,255.25 mi (5,238.82 km) |
| Irvine to Eastpointe (Michigan) | 3,459.83 mi (5,568.05 km) |
| Irvine to Eastvale (California) | 5,100.44 mi (8,208.37 km) |
| Irvine to Eatontown (New Jersey) | 3,229.52 mi (5,197.42 km) |
