| Irvine to East Lake-Orient Park (Florida) | 4,174.77 mi (6,718.64 km) |
| Irvine to East Lansing (Michigan) | 3,502.55 mi (5,636.81 km) |
| Irvine to East Los Angeles (California) | 5,114.53 mi (8,231.05 km) |
| Irvine to East Massapequa (New York) | 3,187.67 mi (5,130.06 km) |
| Irvine to East Meadow (New York) | 3,190.28 mi (5,134.27 km) |
| Irvine to East Milton (Florida) | 4,211.89 mi (6,778.39 km) |
| Irvine to East Moline (Illinois) | 3,775.86 mi (6,076.66 km) |
| Irvine to East Niles (California) | 5,059.78 mi (8,142.93 km) |
| Irvine to East Northport (New York) | 3,173.70 mi (5,107.58 km) |
| Irvine to East Orange (New Jersey) | 3,213.02 mi (5,170.86 km) |
| Irvine to East Palo Alto (California) | 5,031.79 mi (8,097.88 km) |
| Irvine to East Patchogue (New York) | 3,165.75 mi (5,094.78 km) |
| Irvine to East Peoria (Illinois) | 3,787.86 mi (6,095.98 km) |
| Irvine to East Point (Georgia) | 3,956.85 mi (6,367.94 km) |
| Irvine to East Providence (Rhode Island) | 3,055.18 mi (4,916.84 km) |
