| Irvine to Dumas (Texas) | 4,479.27 mi (7,208.69 km) |
| Irvine to Dumont (New Jersey) | 3,196.15 mi (5,143.70 km) |
| Irvine to Duncan (Oklahoma) | 4,408.20 mi (7,094.32 km) |
| Irvine to Duncanville (Texas) | 4,473.94 mi (7,200.11 km) |
| Irvine to Dundalk (Maryland) | 3,371.66 mi (5,426.16 km) |
| Irvine to Dunedin (Florida) | 4,189.14 mi (6,741.76 km) |
| Irvine to Dunkirk (New York) | 3,325.39 mi (5,351.70 km) |
| Irvine to Dunmore (Pennsylvania) | 3,235.45 mi (5,206.95 km) |
| Irvine to Dunwoody (Georgia) | 3,936.75 mi (6,335.59 km) |
| Irvine to Durango (Colorado) | 4,602.28 mi (7,406.66 km) |
| Irvine to Durant (Oklahoma) | 4,382.52 mi (7,052.98 km) |
| Irvine to Durham (North Carolina) | 3,626.36 mi (5,836.06 km) |
| Irvine to Dyer (Indiana) | 3,673.40 mi (5,911.76 km) |
| Irvine to Dyersburg (Tennessee) | 4,017.80 mi (6,466.03 km) |
| Irvine to Eagan (Minnesota) | 3,709.47 mi (5,969.81 km) |
