| Irvine to Dover (New Jersey) | 3,220.59 mi (5,183.03 km) |
| Irvine to Dover (Ohio) | 3,498.86 mi (5,630.87 km) |
| Irvine to Downers Grove (Illinois) | 3,677.11 mi (5,917.73 km) |
| Irvine to Downey (California) | 5,118.87 mi (8,238.03 km) |
| Irvine to Dranesville (Virginia) | 3,418.37 mi (5,501.33 km) |
| Irvine to Draper (Utah) | 4,550.45 mi (7,323.24 km) |
| Irvine to Drexel Heights (Arizona) | 4,994.59 mi (8,038.02 km) |
| Irvine to Drexel Hill (Pennsylvania) | 3,293.52 mi (5,300.41 km) |
| Irvine to Duarte (California) | 5,100.31 mi (8,208.16 km) |
| Irvine to Dublin (California) | 5,010.28 mi (8,063.27 km) |
| Irvine to Dublin (Georgia) | 3,956.95 mi (6,368.09 km) |
| Irvine to Dublin (Ohio) | 3,581.37 mi (5,763.66 km) |
| Irvine to Dubuque (Iowa) | 3,738.37 mi (6,016.33 km) |
| Irvine to Duluth (Georgia) | 3,927.28 mi (6,320.34 km) |
| Irvine to Duluth (Minnesota) | 3,579.06 mi (5,759.94 km) |
