| Irvine to Dixon (Illinois) | 3,727.23 mi (5,998.40 km) |
| Irvine to Dobbs Ferry (New York) | 3,188.29 mi (5,131.06 km) |
| Irvine to Doctor Phillips (Florida) | 4,116.92 mi (6,625.54 km) |
| Irvine to Dodge City (Kansas) | 4,309.53 mi (6,935.52 km) |
| Irvine to Dolton (Illinois) | 3,670.17 mi (5,906.57 km) |
| Irvine to Donna (Texas) | 4,871.62 mi (7,840.11 km) |
| Irvine to Dorado (Puerto Rico) | 4,071.78 mi (6,552.90 km) |
| Irvine to Doral (Florida) | 4,213.85 mi (6,781.53 km) |
| Irvine to Doraville (Georgia) | 3,936.98 mi (6,335.95 km) |
| Irvine to Dothan (Alabama) | 4,119.97 mi (6,630.45 km) |
| Irvine to Douglas (Arizona) | 4,988.52 mi (8,028.25 km) |
| Irvine to Douglas (Georgia) | 4,007.91 mi (6,450.11 km) |
| Irvine to Douglasville (Georgia) | 3,962.22 mi (6,376.58 km) |
| Irvine to Dover (Delaware) | 3,339.75 mi (5,374.80 km) |
| Irvine to Dover (New Hampshire) | 2,974.01 mi (4,786.21 km) |
