| Irvine to Desert Hot Springs (California) | 5,068.47 mi (8,156.92 km) |
| Irvine to DeSoto (Texas) | 4,474.68 mi (7,201.30 km) |
| Irvine to Destin (Florida) | 4,204.91 mi (6,767.14 km) |
| Irvine to Destrehan (Louisiana) | 4,375.83 mi (7,042.22 km) |
| Irvine to Detroit (Michigan) | 3,469.51 mi (5,583.64 km) |
| Irvine to Diamond Bar (California) | 5,105.57 mi (8,216.62 km) |
| Irvine to Diamond Springs (California) | 4,922.67 mi (7,922.27 km) |
| Irvine to Dickinson (North Dakota) | 3,922.66 mi (6,312.92 km) |
| Irvine to Dickinson (Texas) | 4,578.82 mi (7,368.90 km) |
| Irvine to Dickson (Tennessee) | 3,942.24 mi (6,344.42 km) |
| Irvine to Difficult Run (Virginia) | 3,422.10 mi (5,507.33 km) |
| Irvine to Dinuba (California) | 5,005.54 mi (8,055.64 km) |
| Irvine to Discovery Bay (California) | 4,990.55 mi (8,031.52 km) |
| Irvine to Dix Hills (New York) | 3,177.82 mi (5,114.20 km) |
| Irvine to Dixon (California) | 4,965.34 mi (7,990.94 km) |
