| Irvine to Delhi (California) | 4,994.54 mi (8,037.93 km) |
| Irvine to Delray Beach (Florida) | 4,169.07 mi (6,709.47 km) |
| Irvine to Deltona (Florida) | 4,081.84 mi (6,569.09 km) |
| Irvine to Deming (New Mexico) | 4,876.96 mi (7,848.71 km) |
| Irvine to Denison (Texas) | 4,401.55 mi (7,083.61 km) |
| Irvine to Dent (Ohio) | 3,683.13 mi (5,927.43 km) |
| Irvine to Denton (Texas) | 4,451.40 mi (7,163.84 km) |
| Irvine to Dentsville (South Carolina) | 3,801.78 mi (6,118.37 km) |
| Irvine to Denver (Colorado) | 4,366.62 mi (7,027.40 km) |
| Irvine to Depew (New York) | 3,281.72 mi (5,281.42 km) |
| Irvine to Derby (Connecticut) | 3,143.54 mi (5,059.04 km) |
| Irvine to Derby (Kansas) | 4,223.72 mi (6,797.43 km) |
| Irvine to Des Moines (Iowa) | 3,887.32 mi (6,256.04 km) |
| Irvine to Des Moines (Washington) | 4,458.77 mi (7,175.70 km) |
| Irvine to Des Plaines (Illinois) | 3,661.11 mi (5,891.98 km) |
