| Irvine to Decatur (Georgia) | 3,944.99 mi (6,348.85 km) |
| Irvine to Decatur (Illinois) | 3,806.95 mi (6,126.70 km) |
| Irvine to Deer Park (New York) | 3,179.15 mi (5,116.35 km) |
| Irvine to Deer Park (Texas) | 4,568.13 mi (7,351.70 km) |
| Irvine to Deerfield (Illinois) | 3,652.90 mi (5,878.78 km) |
| Irvine to Deerfield Beach (Florida) | 4,178.58 mi (6,724.77 km) |
| Irvine to Defiance (Ohio) | 3,569.26 mi (5,744.17 km) |
| Irvine to DeForest (Wisconsin) | 3,654.01 mi (5,880.55 km) |
| Irvine to DeKalb (Illinois) | 3,696.67 mi (5,949.22 km) |
| Irvine to Del Aire (California) | 5,127.46 mi (8,251.84 km) |
| Irvine to Del City (Oklahoma) | 4,342.40 mi (6,988.41 km) |
| Irvine to Del Rio (Texas) | 4,796.62 mi (7,719.41 km) |
| Irvine to DeLand (Florida) | 4,078.46 mi (6,563.65 km) |
| Irvine to Delano (California) | 5,046.89 mi (8,122.18 km) |
| Irvine to Delaware (Ohio) | 3,570.19 mi (5,745.67 km) |
