| Irvine to Dardenne Prairie (Missouri) | 3,927.96 mi (6,321.44 km) |
| Irvine to Darien (Illinois) | 3,678.32 mi (5,919.68 km) |
| Irvine to Davenport (Iowa) | 3,781.79 mi (6,086.20 km) |
| Irvine to Davidson (North Carolina) | 3,724.91 mi (5,994.66 km) |
| Irvine to Davie (Florida) | 4,196.94 mi (6,754.32 km) |
| Irvine to Davis (California) | 4,956.46 mi (7,976.66 km) |
| Irvine to Dayton (Nevada) | 4,852.75 mi (7,809.75 km) |
| Irvine to Dayton (Ohio) | 3,636.85 mi (5,852.94 km) |
| Irvine to Daytona Beach (Florida) | 4,061.75 mi (6,536.76 km) |
| Irvine to De Pere (Wisconsin) | 3,550.87 mi (5,714.57 km) |
| Irvine to De Witt (New York) | 3,178.08 mi (5,114.63 km) |
| Irvine to Dearborn (Michigan) | 3,476.97 mi (5,595.64 km) |
| Irvine to Dearborn Heights (Michigan) | 3,479.14 mi (5,599.13 km) |
| Irvine to DeBary (Florida) | 4,087.36 mi (6,577.97 km) |
| Irvine to Decatur (Alabama) | 4,005.20 mi (6,445.75 km) |
