| Irvine to Dallas (Texas) | 4,460.68 mi (7,178.78 km) |
| Irvine to Dalton (Georgia) | 3,919.02 mi (6,307.06 km) |
| Irvine to Daly City (California) | 5,028.45 mi (8,092.51 km) |
| Irvine to Damascus (Maryland) | 3,398.40 mi (5,469.20 km) |
| Irvine to Damascus (Oregon) | 4,575.70 mi (7,363.88 km) |
| Irvine to Dana Point (California) | 5,132.44 mi (8,259.87 km) |
| Irvine to Danbury (Connecticut) | 3,154.83 mi (5,077.21 km) |
| Irvine to Dania Beach (Florida) | 4,193.20 mi (6,748.30 km) |
| Irvine to Danville (California) | 5,006.75 mi (8,057.59 km) |
| Irvine to Danville (Illinois) | 3,744.38 mi (6,026.00 km) |
| Irvine to Danville (Indiana) | 3,722.93 mi (5,991.48 km) |
| Irvine to Danville (Kentucky) | 3,765.17 mi (6,059.46 km) |
| Irvine to Danville (Virginia) | 3,615.40 mi (5,818.43 km) |
| Irvine to Daphne (Alabama) | 4,246.32 mi (6,833.78 km) |
| Irvine to Darby (Pennsylvania) | 3,293.25 mi (5,299.98 km) |
