| Irvine to Cloverly (Maryland) | 3,398.88 mi (5,469.97 km) |
| Irvine to Clovis (California) | 4,997.55 mi (8,042.77 km) |
| Irvine to Clovis (New Mexico) | 4,599.51 mi (7,402.20 km) |
| Irvine to Clute (Texas) | 4,614.76 mi (7,426.74 km) |
| Irvine to Coachella (California) | 5,071.19 mi (8,161.30 km) |
| Irvine to Coalinga (California) | 5,056.63 mi (8,137.86 km) |
| Irvine to Coamo (Puerto Rico) | 4,097.17 mi (6,593.75 km) |
| Irvine to Coatesville (Pennsylvania) | 3,311.51 mi (5,329.37 km) |
| Irvine to Cockeysville (Maryland) | 3,366.65 mi (5,418.10 km) |
| Irvine to Cocoa (Florida) | 4,092.34 mi (6,585.99 km) |
| Irvine to Cocoa Beach (Florida) | 4,089.53 mi (6,581.47 km) |
| Irvine to Coconut Creek (Florida) | 4,182.10 mi (6,730.45 km) |
| Irvine to Coeur d'Alene (Idaho) | 4,293.52 mi (6,909.75 km) |
| Irvine to Cohoes (New York) | 3,100.28 mi (4,989.42 km) |
| Irvine to Cold Springs (Nevada) | 4,839.56 mi (7,788.52 km) |
