| Irvine to Ansonia (Connecticut) | 3,142.16 mi (5,056.82 km) |
| Irvine to Antelope (California) | 4,936.32 mi (7,944.25 km) |
| Irvine to Anthem (Arizona) | 4,932.57 mi (7,938.20 km) |
| Irvine to Antioch (California) | 4,991.98 mi (8,033.81 km) |
| Irvine to Antioch (Illinois) | 3,645.68 mi (5,867.15 km) |
| Irvine to Apache Junction (Arizona) | 4,939.51 mi (7,949.37 km) |
| Irvine to Apex (North Carolina) | 3,638.16 mi (5,855.05 km) |
| Irvine to Apollo Beach (Florida) | 4,188.69 mi (6,741.05 km) |
| Irvine to Apopka (Florida) | 4,104.96 mi (6,606.29 km) |
| Irvine to Apple Valley (California) | 5,055.71 mi (8,136.38 km) |
| Irvine to Apple Valley (Minnesota) | 3,714.24 mi (5,977.49 km) |
| Irvine to Appleton (Wisconsin) | 3,569.23 mi (5,744.12 km) |
| Irvine to Arbutus (Maryland) | 3,380.55 mi (5,440.46 km) |
| Irvine to Arcadia (California) | 5,104.56 mi (8,214.99 km) |
| Irvine to Arcata (California) | 4,886.19 mi (7,863.56 km) |
