| Irvine to Alum Rock (California) | 5,028.56 mi (8,092.69 km) |
| Irvine to Alvin (Texas) | 4,591.21 mi (7,388.85 km) |
| Irvine to Amarillo (Texas) | 4,510.68 mi (7,259.24 km) |
| Irvine to Amelia (Ohio) | 3,675.02 mi (5,914.38 km) |
| Irvine to American Canyon (California) | 4,993.41 mi (8,036.12 km) |
| Irvine to American Fork (Utah) | 4,554.97 mi (7,330.51 km) |
| Irvine to Americus (Georgia) | 4,030.69 mi (6,486.76 km) |
| Irvine to Ames (Iowa) | 3,864.76 mi (6,219.74 km) |
| Irvine to Amherst (Ohio) | 3,484.54 mi (5,607.82 km) |
| Irvine to Ammon (Idaho) | 4,388.23 mi (7,062.18 km) |
| Irvine to Amsterdam (New York) | 3,110.82 mi (5,006.38 km) |
| Irvine to Anacortes (Washington) | 4,403.82 mi (7,087.26 km) |
| Irvine to Anaheim (California) | 5,116.16 mi (8,233.67 km) |
| Irvine to Anchorage (Alaska) | 4,140.04 mi (6,662.76 km) |
| Irvine to Anderson (California) | 4,861.27 mi (7,823.46 km) |
