| Irthlingborough to Southern Pines (North Carolina) | 3,897.51 mi (6,272.44 km) |
| Irthlingborough to Southfield (Michigan) | 3,709.52 mi (5,969.90 km) |
| Irthlingborough to Southgate (Michigan) | 3,719.81 mi (5,986.46 km) |
| Irthlingborough to Southlake (Texas) | 4,708.77 mi (7,578.03 km) |
| Irthlingborough to Spanaway (Washington) | 4,758.54 mi (7,658.13 km) |
| Irthlingborough to Spanish Fork (Utah) | 4,835.78 mi (7,782.44 km) |
| Irthlingborough to Spanish Lake (Missouri) | 4,149.27 mi (6,677.60 km) |
| Irthlingborough to Spanish Springs (Nevada) | 5,108.99 mi (8,222.12 km) |
| Irthlingborough to Sparks (Nevada) | 5,115.15 mi (8,232.03 km) |
| Irthlingborough to Spartanburg (South Carolina) | 4,011.57 mi (6,455.99 km) |
| Irthlingborough to Spearfish (South Dakota) | 4,347.98 mi (6,997.40 km) |
| Irthlingborough to Speedway (Indiana) | 3,949.27 mi (6,355.74 km) |
| Irthlingborough to Spencer (Iowa) | 4,118.23 mi (6,627.64 km) |
| Irthlingborough to Spokane (Washington) | 4,591.92 mi (7,389.99 km) |
| Irthlingborough to Spokane Valley (Washington) | 4,586.67 mi (7,381.54 km) |
