| Irthlingborough to Enumclaw (Washington) | 4,741.21 mi (7,630.23 km) |
| Irthlingborough to Ephrata (Pennsylvania) | 3,535.29 mi (5,689.50 km) |
| Irthlingborough to Erie (Colorado) | 4,621.18 mi (7,437.07 km) |
| Irthlingborough to Erie (Pennsylvania) | 3,602.51 mi (5,797.68 km) |
| Irthlingborough to Erlanger (Kentucky) | 3,922.05 mi (6,311.93 km) |
| Irthlingborough to Escanaba (Michigan) | 3,704.81 mi (5,962.32 km) |
| Irthlingborough to Escondido (California) | 5,402.69 mi (8,694.78 km) |
| Irthlingborough to Española (New Mexico) | 4,872.31 mi (7,841.23 km) |
| Irthlingborough to Essex (Maryland) | 3,585.61 mi (5,770.48 km) |
| Irthlingborough to Essex Junction (Vermont) | 3,226.93 mi (5,193.24 km) |
| Irthlingborough to Estelle (Louisiana) | 4,595.28 mi (7,395.38 km) |
| Irthlingborough to Estero (Florida) | 4,431.65 mi (7,132.05 km) |
| Irthlingborough to Euclid (Ohio) | 3,682.58 mi (5,926.55 km) |
| Irthlingborough to Eufaula (Alabama) | 4,291.43 mi (6,906.38 km) |
| Irthlingborough to Eugene (Oregon) | 4,952.53 mi (7,970.32 km) |
