| Irthlingborough to Emeryville (California) | 5,291.40 mi (8,515.68 km) |
| Irthlingborough to Emmaus (Pennsylvania) | 3,492.03 mi (5,619.88 km) |
| Irthlingborough to Emporia (Kansas) | 4,392.32 mi (7,068.76 km) |
| Irthlingborough to Encinitas (California) | 5,413.69 mi (8,712.50 km) |
| Irthlingborough to Endicott (New York) | 3,445.59 mi (5,545.15 km) |
| Irthlingborough to Endwell (New York) | 3,443.03 mi (5,541.03 km) |
| Irthlingborough to Englewood (Colorado) | 4,640.45 mi (7,468.08 km) |
| Irthlingborough to Englewood (Florida) | 4,426.92 mi (7,124.44 km) |
| Irthlingborough to Englewood (New Jersey) | 3,414.97 mi (5,495.86 km) |
| Irthlingborough to Englewood (Ohio) | 3,870.85 mi (6,229.53 km) |
| Irthlingborough to Enid (Oklahoma) | 4,556.33 mi (7,332.71 km) |
| Irthlingborough to Ennis (Texas) | 4,722.03 mi (7,599.37 km) |
| Irthlingborough to Ensley (Florida) | 4,446.94 mi (7,156.65 km) |
| Irthlingborough to Enterprise (Alabama) | 4,348.80 mi (6,998.72 km) |
| Irthlingborough to Enterprise (Nevada) | 5,179.62 mi (8,335.79 km) |
