| Irthlingborough to Shotley Bridge | 183.17 mi (294.79 km) |
| Irthlingborough to Shrewsbury | 93.80 mi (150.96 km) |
| Irthlingborough to Sidcup | 69.14 mi (111.28 km) |
| Irthlingborough to Sidmouth | 160.13 mi (257.71 km) |
| Irthlingborough to Sileby | 34.91 mi (56.18 km) |
| Irthlingborough to Sittingbourne | 89.24 mi (143.62 km) |
| Irthlingborough to Skegness | 69.35 mi (111.60 km) |
| Irthlingborough to Skelmersdale | 123.61 mi (198.92 km) |
| Irthlingborough to Skipton | 127.25 mi (204.79 km) |
| Irthlingborough to Sleaford | 47.19 mi (75.94 km) |
| Irthlingborough to Slough | 56.36 mi (90.71 km) |
| Irthlingborough to Small Heath | 53.16 mi (85.56 km) |
| Irthlingborough to Smethwick | 58.28 mi (93.79 km) |
| Irthlingborough to Snaresbrook | 57.53 mi (92.58 km) |
| Irthlingborough to Snodland | 82.38 mi (132.58 km) |
