| Iowa City to Superior (Colorado) | 721.93 mi (1,161.84 km) |
| Iowa City to Superior (Wisconsin) | 349.18 mi (561.94 km) |
| Iowa City to Surprise (Arizona) | 1,265.47 mi (2,036.58 km) |
| Iowa City to Susanville (California) | 1,510.87 mi (2,431.50 km) |
| Iowa City to Sussex (Wisconsin) | 197.27 mi (317.48 km) |
| Iowa City to Suwanee (Georgia) | 664.11 mi (1,068.79 km) |
| Iowa City to Swansea (Illinois) | 229.54 mi (369.41 km) |
| Iowa City to Sweetwater (Florida) | 1,268.00 mi (2,040.65 km) |
| Iowa City to Sweetwater (Texas) | 800.61 mi (1,288.45 km) |
| Iowa City to Sycamore (Illinois) | 148.50 mi (238.99 km) |
| Iowa City to Sylacauga (Alabama) | 652.92 mi (1,050.78 km) |
| Iowa City to Sylvania (Ohio) | 403.46 mi (649.30 km) |
| Iowa City to Syosset (New York) | 936.81 mi (1,507.64 km) |
| Iowa City to Syracuse (New York) | 790.38 mi (1,271.99 km) |
| Iowa City to Syracuse (Utah) | 1,063.20 mi (1,711.05 km) |
