| Iowa City to Southern Pines (North Carolina) | 792.68 mi (1,275.69 km) |
| Iowa City to Southfield (Michigan) | 427.78 mi (688.44 km) |
| Iowa City to Southgate (Michigan) | 429.41 mi (691.07 km) |
| Iowa City to Southlake (Texas) | 675.51 mi (1,087.13 km) |
| Iowa City to Spanaway (Washington) | 1,560.24 mi (2,510.96 km) |
| Iowa City to Spanish Fork (Utah) | 1,053.51 mi (1,695.46 km) |
| Iowa City to Spanish Lake (Missouri) | 210.04 mi (338.03 km) |
| Iowa City to Spanish Springs (Nevada) | 1,474.82 mi (2,373.49 km) |
| Iowa City to Sparks (Nevada) | 1,478.67 mi (2,379.69 km) |
| Iowa City to Spartanburg (South Carolina) | 696.54 mi (1,120.97 km) |
| Iowa City to Spearfish (South Dakota) | 649.51 mi (1,045.28 km) |
| Iowa City to Speedway (Indiana) | 304.98 mi (490.81 km) |
| Iowa City to Spencer (Iowa) | 211.59 mi (340.52 km) |
| Iowa City to Spokane (Washington) | 1,331.68 mi (2,143.13 km) |
| Iowa City to Spokane Valley (Washington) | 1,322.51 mi (2,128.37 km) |
