| Iowa City to Silver Firs (Washington) | 1,550.81 mi (2,495.79 km) |
| Iowa City to Silver Spring (Maryland) | 784.89 mi (1,263.15 km) |
| Iowa City to Silver Springs Shores (Florida) | 1,017.49 mi (1,637.49 km) |
| Iowa City to Silverdale (Washington) | 1,574.51 mi (2,533.93 km) |
| Iowa City to Silverton (Oregon) | 1,577.57 mi (2,538.85 km) |
| Iowa City to Simi Valley (California) | 1,560.37 mi (2,511.17 km) |
| Iowa City to Simpsonville (South Carolina) | 693.95 mi (1,116.81 km) |
| Iowa City to Sioux City (Iowa) | 255.86 mi (411.77 km) |
| Iowa City to Sioux Falls (South Dakota) | 294.73 mi (474.32 km) |
| Iowa City to Skokie (Illinois) | 196.83 mi (316.77 km) |
| Iowa City to Sleepy Hollow (New York) | 914.76 mi (1,472.16 km) |
| Iowa City to Slidell (Louisiana) | 791.40 mi (1,273.64 km) |
| Iowa City to Smithfield (North Carolina) | 827.42 mi (1,331.60 km) |
| Iowa City to Smithfield (Utah) | 1,043.93 mi (1,680.04 km) |
| Iowa City to Smithville (Missouri) | 223.66 mi (359.94 km) |
