| Iowa City to Scottsboro (Alabama) | 568.41 mi (914.76 km) |
| Iowa City to Scottsdale (Arizona) | 1,236.71 mi (1,990.29 km) |
| Iowa City to Scranton (Pennsylvania) | 819.64 mi (1,319.09 km) |
| Iowa City to Seabrook (Maryland) | 794.07 mi (1,277.94 km) |
| Iowa City to Seabrook (Texas) | 857.24 mi (1,379.59 km) |
| Iowa City to Seaford (New York) | 939.05 mi (1,511.25 km) |
| Iowa City to Seagoville (Texas) | 680.27 mi (1,094.79 km) |
| Iowa City to Seal Beach (California) | 1,542.56 mi (2,482.50 km) |
| Iowa City to Searcy (Arkansas) | 443.31 mi (713.44 km) |
| Iowa City to Seaside (California) | 1,651.04 mi (2,657.09 km) |
| Iowa City to SeaTac (Washington) | 1,555.67 mi (2,503.60 km) |
| Iowa City to Seattle (Washington) | 1,557.66 mi (2,506.81 km) |
| Iowa City to Sebastian (Florida) | 1,143.45 mi (1,840.20 km) |
| Iowa City to Sebring (Florida) | 1,133.20 mi (1,823.70 km) |
| Iowa City to Secaucus (New Jersey) | 908.11 mi (1,461.47 km) |
