| Iowa City to Santa Rosa (California) | 1,654.59 mi (2,662.81 km) |
| Iowa City to Santaquin (Utah) | 1,063.54 mi (1,711.61 km) |
| Iowa City to Santee (California) | 1,518.84 mi (2,444.33 km) |
| Iowa City to Sapulpa (Oklahoma) | 461.05 mi (741.99 km) |
| Iowa City to Saraland (Alabama) | 770.64 mi (1,240.23 km) |
| Iowa City to Sarasota (Florida) | 1,112.19 mi (1,789.90 km) |
| Iowa City to Sarasota Springs (Florida) | 1,115.85 mi (1,795.79 km) |
| Iowa City to Saratoga (California) | 1,645.82 mi (2,648.69 km) |
| Iowa City to Saratoga Springs (New York) | 909.85 mi (1,464.26 km) |
| Iowa City to Saratoga Springs (Utah) | 1,064.34 mi (1,712.89 km) |
| Iowa City to Sartell (Minnesota) | 305.03 mi (490.89 km) |
| Iowa City to Satellite Beach (Florida) | 1,116.14 mi (1,796.25 km) |
| Iowa City to Sauk Rapids (Minnesota) | 302.29 mi (486.49 km) |
| Iowa City to Sault Ste. Marie (Michigan) | 486.91 mi (783.61 km) |
| Iowa City to Savage (Minnesota) | 233.13 mi (375.18 km) |
