| Iowa City to Sanford (Maine) | 1,061.76 mi (1,708.73 km) |
| Iowa City to Sanford (North Carolina) | 790.59 mi (1,272.33 km) |
| Iowa City to Sanger (California) | 1,532.46 mi (2,466.25 km) |
| Iowa City to Santa Ana (California) | 1,533.57 mi (2,468.04 km) |
| Iowa City to Santa Barbara (California) | 1,604.76 mi (2,582.61 km) |
| Iowa City to Santa Clara (California) | 1,640.53 mi (2,640.18 km) |
| Iowa City to Santa Clara (Oregon) | 1,599.06 mi (2,573.43 km) |
| Iowa City to Santa Clarita (California) | 1,542.79 mi (2,482.88 km) |
| Iowa City to Santa Cruz (California) | 1,653.24 mi (2,660.63 km) |
| Iowa City to Santa Fe (New Mexico) | 881.24 mi (1,418.22 km) |
| Iowa City to Santa Fe (Texas) | 870.79 mi (1,401.40 km) |
| Iowa City to Santa Fe Springs (California) | 1,536.25 mi (2,472.36 km) |
| Iowa City to Santa Maria (California) | 1,626.50 mi (2,617.60 km) |
| Iowa City to Santa Monica (California) | 1,554.50 mi (2,501.73 km) |
| Iowa City to Santa Paula (California) | 1,573.70 mi (2,532.63 km) |
