| Iowa City to San Luis Obispo (California) | 1,628.39 mi (2,620.64 km) |
| Iowa City to San Marcos (California) | 1,518.45 mi (2,443.71 km) |
| Iowa City to San Marcos (Texas) | 889.10 mi (1,430.86 km) |
| Iowa City to San Marino (California) | 1,532.69 mi (2,466.63 km) |
| Iowa City to San Mateo (California) | 1,653.92 mi (2,661.72 km) |
| Iowa City to San Pablo (California) | 1,646.21 mi (2,649.31 km) |
| Iowa City to San Rafael (California) | 1,654.86 mi (2,663.24 km) |
| Iowa City to San Ramon (California) | 1,629.73 mi (2,622.79 km) |
| Iowa City to San Tan Valley (Arizona) | 1,241.33 mi (1,997.73 km) |
| Iowa City to Sand Springs (Oklahoma) | 454.40 mi (731.28 km) |
| Iowa City to Sandusky (Ohio) | 456.49 mi (734.65 km) |
| Iowa City to Sandy (Oregon) | 1,551.72 mi (2,497.25 km) |
| Iowa City to Sandy (Utah) | 1,057.98 mi (1,702.65 km) |
| Iowa City to Sandy Springs (Georgia) | 660.72 mi (1,063.33 km) |
| Iowa City to Sanford (Florida) | 1,059.02 mi (1,704.34 km) |
