| Iowa City to Enterprise (Nevada) | 1,328.89 mi (2,138.64 km) |
| Iowa City to Enumclaw (Washington) | 1,540.25 mi (2,478.79 km) |
| Iowa City to Ephrata (Pennsylvania) | 806.73 mi (1,298.31 km) |
| Iowa City to Erie (Colorado) | 714.08 mi (1,149.21 km) |
| Iowa City to Erie (Pennsylvania) | 589.74 mi (949.10 km) |
| Iowa City to Erlanger (Kentucky) | 408.67 mi (657.69 km) |
| Iowa City to Escanaba (Michigan) | 359.21 mi (578.09 km) |
| Iowa City to Escondido (California) | 1,513.36 mi (2,435.52 km) |
| Iowa City to Española (New Mexico) | 872.95 mi (1,404.88 km) |
| Iowa City to Essex (Maryland) | 808.20 mi (1,300.68 km) |
| Iowa City to Essex Junction (Vermont) | 947.73 mi (1,525.22 km) |
| Iowa City to Estelle (Louisiana) | 819.96 mi (1,319.60 km) |
| Iowa City to Estero (Florida) | 1,188.76 mi (1,913.12 km) |
| Iowa City to Euclid (Ohio) | 516.82 mi (831.74 km) |
| Iowa City to Eufaula (Alabama) | 759.74 mi (1,222.68 km) |
