| Indianapolis to University Place (Washington) | 1,876.59 mi (3,020.09 km) |
| Indianapolis to Upland (California) | 1,773.83 mi (2,854.70 km) |
| Indianapolis to Upper Arlington (Ohio) | 163.91 mi (263.79 km) |
| Indianapolis to Upper Grand Lagoon (Florida) | 664.25 mi (1,069.01 km) |
| Indianapolis to Upper Montclair (New Jersey) | 633.15 mi (1,018.96 km) |
| Indianapolis to Urbana (Illinois) | 111.09 mi (178.78 km) |
| Indianapolis to Urbana (Maryland) | 469.84 mi (756.13 km) |
| Indianapolis to Urbana (Ohio) | 128.74 mi (207.19 km) |
| Indianapolis to Urbandale (Iowa) | 419.92 mi (675.79 km) |
| Indianapolis to Utica (New York) | 609.75 mi (981.30 km) |
| Indianapolis to Uvalde (Texas) | 1,063.07 mi (1,710.84 km) |
| Indianapolis to Vacaville (California) | 1,911.27 mi (3,075.90 km) |
| Indianapolis to Vadnais Heights (Minnesota) | 507.56 mi (816.85 km) |
| Indianapolis to Vail (Arizona) | 1,468.78 mi (2,363.78 km) |
| Indianapolis to Valdosta (Georgia) | 637.51 mi (1,025.98 km) |
