| Indianapolis to Superior (Colorado) | 1,006.60 mi (1,619.97 km) |
| Indianapolis to Superior (Wisconsin) | 563.27 mi (906.49 km) |
| Indianapolis to Surprise (Arizona) | 1,510.15 mi (2,430.35 km) |
| Indianapolis to Susanville (California) | 1,810.56 mi (2,913.82 km) |
| Indianapolis to Sussex (Wisconsin) | 255.67 mi (411.47 km) |
| Indianapolis to Suwanee (Georgia) | 411.92 mi (662.92 km) |
| Indianapolis to Swansea (Illinois) | 222.46 mi (358.01 km) |
| Indianapolis to Sweetwater (Florida) | 1,023.01 mi (1,646.38 km) |
| Indianapolis to Sweetwater (Texas) | 940.88 mi (1,514.20 km) |
| Indianapolis to Sycamore (Illinois) | 202.59 mi (326.03 km) |
| Indianapolis to Sylacauga (Alabama) | 456.00 mi (733.86 km) |
| Indianapolis to Sylvania (Ohio) | 184.66 mi (297.18 km) |
| Indianapolis to Syosset (New York) | 669.56 mi (1,077.56 km) |
| Indianapolis to Syracuse (New York) | 564.76 mi (908.90 km) |
| Indianapolis to Syracuse (Utah) | 1,361.38 mi (2,190.92 km) |
