| Indianapolis to Southern Pines (North Carolina) | 486.52 mi (782.98 km) |
| Indianapolis to Southfield (Michigan) | 239.42 mi (385.30 km) |
| Indianapolis to Southgate (Michigan) | 227.22 mi (365.68 km) |
| Indianapolis to Southlake (Texas) | 771.69 mi (1,241.92 km) |
| Indianapolis to Spanaway (Washington) | 1,870.50 mi (3,010.27 km) |
| Indianapolis to Spanish Fork (Utah) | 1,346.06 mi (2,166.27 km) |
| Indianapolis to Spanish Lake (Missouri) | 227.69 mi (366.44 km) |
| Indianapolis to Spanish Springs (Nevada) | 1,771.14 mi (2,850.37 km) |
| Indianapolis to Sparks (Nevada) | 1,774.69 mi (2,856.10 km) |
| Indianapolis to Spartanburg (South Carolina) | 406.37 mi (653.98 km) |
| Indianapolis to Spearfish (South Dakota) | 959.80 mi (1,544.65 km) |
| Indianapolis to Speedway (Indiana) | 5.55 mi (8.93 km) |
| Indianapolis to Spencer (Iowa) | 520.89 mi (838.29 km) |
| Indianapolis to Spokane (Washington) | 1,641.41 mi (2,641.59 km) |
| Indianapolis to Spokane Valley (Washington) | 1,632.22 mi (2,626.80 km) |
