| Indianapolis to Silver Firs (Washington) | 1,860.66 mi (2,994.44 km) |
| Indianapolis to Silver Spring (Maryland) | 489.98 mi (788.54 km) |
| Indianapolis to Silver Springs Shores (Florida) | 773.27 mi (1,244.46 km) |
| Indianapolis to Silverdale (Washington) | 1,884.51 mi (3,032.82 km) |
| Indianapolis to Silverton (Oregon) | 1,887.31 mi (3,037.33 km) |
| Indianapolis to Simi Valley (California) | 1,827.78 mi (2,941.53 km) |
| Indianapolis to Simpsonville (South Carolina) | 409.05 mi (658.31 km) |
| Indianapolis to Sioux City (Iowa) | 564.77 mi (908.91 km) |
| Indianapolis to Sioux Falls (South Dakota) | 604.50 mi (972.85 km) |
| Indianapolis to Skokie (Illinois) | 176.88 mi (284.66 km) |
| Indianapolis to Sleepy Hollow (New York) | 651.28 mi (1,048.14 km) |
| Indianapolis to Slidell (Louisiana) | 686.94 mi (1,105.52 km) |
| Indianapolis to Smithfield (North Carolina) | 518.05 mi (833.72 km) |
| Indianapolis to Smithfield (Utah) | 1,345.51 mi (2,165.39 km) |
| Indianapolis to Smithville (Missouri) | 449.45 mi (723.33 km) |
