| Indianapolis to Scottsboro (Alabama) | 354.72 mi (570.86 km) |
| Indianapolis to Scottsdale (Arizona) | 1,479.16 mi (2,380.49 km) |
| Indianapolis to Scranton (Pennsylvania) | 560.91 mi (902.70 km) |
| Indianapolis to Seabrook (Maryland) | 499.26 mi (803.49 km) |
| Indianapolis to Seabrook (Texas) | 865.75 mi (1,393.29 km) |
| Indianapolis to Seaford (New York) | 669.79 mi (1,077.93 km) |
| Indianapolis to Seagoville (Texas) | 759.56 mi (1,222.39 km) |
| Indianapolis to Seal Beach (California) | 1,805.16 mi (2,905.13 km) |
| Indianapolis to Searcy (Arkansas) | 438.04 mi (704.95 km) |
| Indianapolis to Seaside (California) | 1,936.39 mi (3,116.31 km) |
| Indianapolis to SeaTac (Washington) | 1,865.78 mi (3,002.68 km) |
| Indianapolis to Seattle (Washington) | 1,867.67 mi (3,005.73 km) |
| Indianapolis to Sebastian (Florida) | 889.79 mi (1,431.98 km) |
| Indianapolis to Sebring (Florida) | 891.33 mi (1,434.46 km) |
| Indianapolis to Secaucus (New Jersey) | 640.00 mi (1,029.98 km) |
