| Indianapolis to Santa Rosa (California) | 1,948.57 mi (3,135.92 km) |
| Indianapolis to Santaquin (Utah) | 1,355.38 mi (2,181.27 km) |
| Indianapolis to Santee (California) | 1,772.49 mi (2,852.54 km) |
| Indianapolis to Sapulpa (Oklahoma) | 601.50 mi (968.02 km) |
| Indianapolis to Saraland (Alabama) | 626.66 mi (1,008.52 km) |
| Indianapolis to Sarasota (Florida) | 883.86 mi (1,422.44 km) |
| Indianapolis to Sarasota Springs (Florida) | 886.81 mi (1,427.18 km) |
| Indianapolis to Saratoga (California) | 1,934.31 mi (3,112.97 km) |
| Indianapolis to Saratoga Springs (New York) | 679.14 mi (1,092.97 km) |
| Indianapolis to Saratoga Springs (Utah) | 1,358.47 mi (2,186.24 km) |
| Indianapolis to Sartell (Minnesota) | 574.80 mi (925.05 km) |
| Indianapolis to Satellite Beach (Florida) | 861.57 mi (1,386.57 km) |
| Indianapolis to Sauk Rapids (Minnesota) | 571.44 mi (919.64 km) |
| Indianapolis to Sault Ste. Marie (Michigan) | 471.76 mi (759.23 km) |
| Indianapolis to Savage (Minnesota) | 504.06 mi (811.21 km) |
