| Indianapolis to San Diego (California) | 1,780.42 mi (2,865.31 km) |
| Indianapolis to San Diego Country Estates (California) | 1,757.65 mi (2,828.67 km) |
| Indianapolis to San Dimas (California) | 1,781.96 mi (2,867.79 km) |
| Indianapolis to San Fernando (California) | 1,810.61 mi (2,913.90 km) |
| Indianapolis to San Francisco (California) | 1,947.12 mi (3,133.59 km) |
| Indianapolis to San Gabriel (California) | 1,797.69 mi (2,893.10 km) |
| Indianapolis to San Germán (Puerto Rico) | 1,883.37 mi (3,030.99 km) |
| Indianapolis to San Jacinto (California) | 1,746.80 mi (2,811.20 km) |
| Indianapolis to San Jose (California) | 1,924.27 mi (3,096.81 km) |
| Indianapolis to San Juan (Puerto Rico) | 1,901.51 mi (3,060.18 km) |
| Indianapolis to San Juan (Texas) | 1,166.10 mi (1,876.65 km) |
| Indianapolis to San Juan Capistrano (California) | 1,789.88 mi (2,880.53 km) |
| Indianapolis to San Leandro (California) | 1,933.01 mi (3,110.89 km) |
| Indianapolis to San Lorenzo (California) | 1,932.24 mi (3,109.64 km) |
| Indianapolis to San Luis (Arizona) | 1,663.26 mi (2,676.77 km) |
