| Indianapolis to Orangevale (California) | 1,866.63 mi (3,004.05 km) |
| Indianapolis to Orchards (Washington) | 1,874.10 mi (3,016.07 km) |
| Indianapolis to Orcutt (California) | 1,901.66 mi (3,060.42 km) |
| Indianapolis to Oregon (Ohio) | 192.30 mi (309.47 km) |
| Indianapolis to Oregon (Wisconsin) | 274.93 mi (442.46 km) |
| Indianapolis to Oregon City (Oregon) | 1,877.47 mi (3,021.49 km) |
| Indianapolis to Orem (Utah) | 1,347.55 mi (2,168.67 km) |
| Indianapolis to Orinda (California) | 1,930.83 mi (3,107.38 km) |
| Indianapolis to Orland Park (Illinois) | 155.16 mi (249.70 km) |
| Indianapolis to Orlando (Florida) | 827.41 mi (1,331.58 km) |
| Indianapolis to Ormond Beach (Florida) | 778.48 mi (1,252.84 km) |
| Indianapolis to Oro Valley (Arizona) | 1,470.58 mi (2,366.67 km) |
| Indianapolis to Oroville (California) | 1,872.11 mi (3,012.88 km) |
| Indianapolis to Oshkosh (Wisconsin) | 318.53 mi (512.63 km) |
| Indianapolis to Oskaloosa (Iowa) | 356.64 mi (573.96 km) |
