| Indianapolis to Olympia Heights (Florida) | 1,027.30 mi (1,653.28 km) |
| Indianapolis to Omaha (Nebraska) | 530.07 mi (853.06 km) |
| Indianapolis to On Top of the World Designated Place (Florida) | 769.19 mi (1,237.89 km) |
| Indianapolis to Onalaska (Wisconsin) | 385.32 mi (620.11 km) |
| Indianapolis to Oneida (New York) | 588.49 mi (947.09 km) |
| Indianapolis to Oneonta (New York) | 605.13 mi (973.86 km) |
| Indianapolis to Ontario (California) | 1,773.00 mi (2,853.37 km) |
| Indianapolis to Ontario (Oregon) | 1,602.68 mi (2,579.26 km) |
| Indianapolis to Opa-locka (Florida) | 1,017.34 mi (1,637.26 km) |
| Indianapolis to Opelika (Alabama) | 493.52 mi (794.24 km) |
| Indianapolis to Opelousas (Louisiana) | 721.41 mi (1,161.00 km) |
| Indianapolis to Orange (California) | 1,790.61 mi (2,881.72 km) |
| Indianapolis to Orange (Texas) | 793.58 mi (1,277.15 km) |
| Indianapolis to Orange City (Florida) | 798.38 mi (1,284.86 km) |
| Indianapolis to Orangeburg (South Carolina) | 523.39 mi (842.32 km) |
