| Imperial Beach to Southern Pines (North Carolina) | 2,158.01 mi (3,472.98 km) |
| Imperial Beach to Southfield (Michigan) | 1,961.94 mi (3,157.44 km) |
| Imperial Beach to Southgate (Michigan) | 1,961.81 mi (3,157.23 km) |
| Imperial Beach to Southlake (Texas) | 1,158.74 mi (1,864.81 km) |
| Imperial Beach to Spanaway (Washington) | 1,041.91 mi (1,676.78 km) |
| Imperial Beach to Spanish Fork (Utah) | 603.34 mi (970.98 km) |
| Imperial Beach to Spanish Lake (Missouri) | 1,563.83 mi (2,516.74 km) |
| Imperial Beach to Spanish Springs (Nevada) | 509.92 mi (820.64 km) |
| Imperial Beach to Sparks (Nevada) | 505.16 mi (812.98 km) |
| Imperial Beach to Spartanburg (South Carolina) | 2,017.92 mi (3,247.53 km) |
| Imperial Beach to Spearfish (South Dakota) | 1,090.47 mi (1,754.94 km) |
| Imperial Beach to Speedway (Indiana) | 1,782.51 mi (2,868.67 km) |
| Imperial Beach to Spencer (Iowa) | 1,397.01 mi (2,248.27 km) |
| Imperial Beach to Spokane (Washington) | 1,043.29 mi (1,679.01 km) |
| Imperial Beach to Spokane Valley (Washington) | 1,042.86 mi (1,678.33 km) |
